Silicified Microcrystalline Cellulose USP/NF

Compound of Microcrystalline Cellulose USP/NF,EP, JP and Colloidal Silicon Dioxide USP/NF,EP,JP


Avicel SMCC, a high functionality co-processed spray-dried excipient comprising of 98 percent of microcrystalline cellulose (MCC) and 2 percent of colloidal silicon dioxide. Silicification reduces cohesiveness of the powder blend thus enhancing flow properties compared to MCC. It increases the surface area, which improves the binding properties of MCC. It also results in better compactibility, provides excellent homogeneity and content uniformity even for low-dosed, micronized active ingredients.  



Mean Particle Size

µm (d50)*

Bulk density



Avicel SMCC 50

45 – 80

0.25 - 0.37

Filler-binder for direct compression


Cushioning agent, diluent and dry binder for MUPS

Avicel SMCC 90

90 – 150

0.25 - 0.37

Avicel SMCC HD 90

90 - 160

0.38 - 0.50

*As determined by Laser diffraction





This browser is not supported. For a better experience on Signet, update your browser.